Psen2^tm1Haa
Targeted Allele Detail

Summary

• Symbol: Psen2^tm1Haa
• Name: presenilin 2; targeted mutation 1, Christian Haass
• MGI ID: MGI:2664242
• Synonyms: PS2^-
• Gene: Psen2 Location: Chr1:180054569-180091003 bp, - strand Genetic Position: Chr1, 84.19 cM
• Alliance: Psen2^tm1Haa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83860
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 5 via homologous recombination. Absence of gene expression was confirmed by Northern and Western blot analysis of brain lysates from homozygous mutant animals. (J:83860)

Disease models

Expression

In Mice Carrying this Mutation:

52043 assay results 4 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psen2 Mutation: 32 strains or lines available

References

• Original: J:83860 Steiner H, et al., A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem. 1999 Oct 1;274(40):28669-73
• All: 41 reference(s)