Prkcq^tm1Litt
Targeted Allele Detail

Summary

• Symbol: Prkcq^tm1Litt
• Name: protein kinase C, theta; targeted mutation 1, Dan Littman
• MGI ID: MGI:2664379
• Synonyms: PKCtheta^-, PKC-Theta^-
• Gene: Prkcq Location: Chr2:11176922-11306033 bp, + strand Genetic Position: Chr2, 8.42 cM
• Alliance: Prkcq^tm1Litt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83922
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the ATP-binding site of the kinase domain (aa 396 - 451) was replaced with a neo cassette inserted by homologous recombination. Protein was undetected in thymocytes or T cells obtained from mutant mice. (J:83922)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Prkcq Mutation: 51 strains or lines available

References

• Original: J:83922 Sun Z, et al., PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes. Nature. 2000 Mar 23;404(6776):402-7
• All: 86 reference(s)