Bin1^tm1Gcp
Targeted Allele Detail

Summary

• Symbol: Bin1^tm1Gcp
• Name: bridging integrator 1; targeted mutation 1, George C Prendergast
• MGI ID: MGI:2664484
• Synonyms: Bin1^-
• Gene: Bin1 Location: Chr18:32510283-32568790 bp, + strand Genetic Position: Chr18, 18.01 cM
• Alliance: Bin1^tm1Gcp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83753
• Parent Cell Line: IT2 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacing the region encoding the BAR domain (part of exon 3 and all of exons 4 and 5) with a neomycin resistance cassette. Absence of gene expression was confirmed by Western blot analysis of embyronic fibrobasts derived from homozygous mutants. (J:83753)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bin1 Mutation: 29 strains or lines available

References

• Original: J:83753 Muller AJ, et al., Targeted disruption of the murine Bin1/Amphiphysin II gene does not disable endocytosis but results in embryonic cardiomyopathy with aberrant myofibril formation. Mol Cell Biol. 2003 Jun;23(12):4295-306
• All: 4 reference(s)