Tmod2^tm1Hzo
Targeted Allele Detail

Summary

• Symbol: Tmod2^tm1Hzo
• Name: tropomodulin 2; targeted mutation 1, Huda Y Zoghbi
• MGI ID: MGI:2664500
• Synonyms: A12, Tmod2^lacZ-
• Gene: Tmod2 Location: Chr9:75472903-75518607 bp, - strand Genetic Position: Chr9, 42.31 cM
• Alliance: Tmod2^tm1Hzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83752
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was deleted and replaced with an in-frame lacZ-PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of brain proteins from homozygous mutant animals. (J:83752)

Expression

In Mice Carrying this Mutation:

37 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmod2 Mutation: 18 strains or lines available

References

• Original: J:83752 Cox PR, et al., Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory. Mol Cell Neurosci. 2003 May;23(1):1-12
• All: 1 reference(s)