Aod1a^A/J
QTL Variant Detail

Summary

• QTL variant: Aod1a^A/J
• Name: autoimmune ovarian dysgenesis 1a; A/J
• MGI ID: MGI:2664522
• QTL: Aod1a Location: Chr16:35446643-92573008 bp Genetic Position: Chr16, Syntenic

Variant origin

• Strain of Specimen: A/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers susceptibility to autoimmune oophoritis compared to C57BL/6J. (J:83714)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83714

With the use of recombinant inbred congenic lines derived from parental strains C57BL/6J and A/J, Aod1 was resolved into 2 separate QTLs named Aod1a and Aod1b. Parental strain C57BL/6J is resistant to autoimmune oophoritis while parental strain A/J is susceptible.

Aod1a spans 23.3 cM (D16Mit211) to 66.75 cM (D16Mit51) on mouse Chromosome 16 with A/J-derived alleles conferring susceptibility to autoimmune oophoritis. Previously identified autoimmune QTLs Eae11 and Pgia10 colocalize to the Aod1a interval. Candidate genes for Aod1a include Ifnar1, Il10rb, and Runx1. Candidate genes Cd86 and Cd80 have been excluded for Aod1a.

Aod1b spans 20.9 cM (D16Mit89) to 23.3 cM (D16Mit211) on mouse Chromosome 16 with A/J-derived alleles conferring resistance to autoimmune oophoritis. Previously identified QTL Lprm5 colocalizes with Aod1b. Possible candidate genes for Aod1b are Trfr, Stfa1, Stfa2, and Stfa3. Sequence analysis revealed multiple nonconserved amino acid sequence polymorphism between C57BL/6J and A/J inStfa1 and Stfa2, but not Stfa3.

References

• Original: J:83714 Roper RJ, et al., Aod1 controlling day 3 thymectomy-induced autoimmune ovarian dysgenesis in mice encompasses two linked quantitative trait loci with opposing allelic effects on disease susceptibility. J Immunol. 2003 Jun 15;170(12):5886-91
• All: 1 reference(s)