Hypch^NZO/HlBom
QTL Variant Detail

Summary

• QTL variant: Hypch^NZO/HlBom
• Name: hypercholesterolemia; NZO/HlBom
• MGI ID: MGI:2664816
• QTL: Hypch Location: Chr5:109238624-139118905 bp Genetic Position: Chr5, cM position of peak correlated region/allele: 67.67 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: NZO/HlBom

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased serum cholesterol compared to SJL/NBom. (J:83735)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:83735

Genome scan was performed on 100 male NZO/HlBom x (SJL/NBom x NZO/HlBom)F1 backcross animals to identify QTLs associated with diet-induced obesity and hypercholesterolemia. Parental strain NZO/HlBom exhibits 2-fold increased body weight and plasma cholesterol at 22 weeks of age on a high fat diet compared to lean parental strain SJL/NBom. A single QTL at 72 cM on mouse Chromosome 5, Hypch, was identified in association with elevated serum cholesterol, but not elevated body weight. Hypch gives peak linkage at D5Mit244 with LOD=7.3 on a standard diet and LOD=13.5 on a high fat diet. NZO/HlBom-derived alleles confer elevated serum cholesterol at this locus. The QTL interval spans approximately 59 cM to 79 cM with markers D5Mit240 and D5Mit374 flanking the region, respectively. Hypch maps near previously identified cholesterol QTLs Hdlq1 and Hdl2, and obesity QTL Nob1.

References

• Original: J:83735 Giesen K, et al., Diet-dependent obesity and hypercholesterolemia in the New Zealand obese mouse: identification of a quantitative trait locus for elevated serum cholesterol on the distal mouse chromosome 5. Biochem Biophys Res Commun. 2003 May 16;304(4):812-7
• All: 1 reference(s)