Tauph^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Tauph^C57BL/6J
• Name: tau phosphorylation; C57BL/6J
• MGI ID: MGI:2664871
• QTL: Tauph Location: Chr16:86076132-86076354 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 48.89 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers decreased tau phosphorylation compared to BALB/cByJ.
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:81203

Genome scan was performed on a population of (BALB/cByJ-Dab1^tm2Cpr x C57BL/6J)F2 animals to identify QTLs associated with tau phosphorylation. The Dab1^tm2Cpr mutation is viable on a BALB/cByJ background but not on a 129/Sv x C57BL/6J mixed background. A significant QTL associated with tau phosphorylation, Tauph, mapped to 60 cM on mouse Chromosome 16 with a LOD score of 3.2 at D16Mit224. BALB/cByJ-derived alleles confer increased tau phosphorlyation in a dominant manner at this locus. Possible candidate genes near Tauph are Sod1 and App. Suggestive QTLs mapped to mouse Chromosomes 1 (D1Mit365), 12 (D12Mit014), and 17 (D17Mit142).

References

• Original: J:81203 Brich J, et al., Genetic modulation of tau phosphorylation in the mouse. J Neurosci. 2003 Jan 1;23(1):187-92
• All: 1 reference(s)