Men1^tm1.1Zqw
Targeted Allele Detail

Summary

• Symbol: Men1^tm1.1Zqw
• Name: multiple endocrine neoplasia 1; targeted mutation 1.1, Zhao-Qi Wang
• MGI ID: MGI:2664873
• Synonyms: Men1^D, Men1^delta, Men1^Δ
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm1.1Zqw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83882
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was derived from Men1^tm1Zqw by transfecting targeted ES cells with a Cre-expressing plasmid (pMC-Cre). The neo gene, TK gene, and exon 3 were then removed by Cre-mediated recombination. Western blot analysis demonstrated that no detectable protein product is expressed from this allele in mutant ES cells. (J:83882)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

References

• Original: J:83882 Bertolino P, et al., Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech Dev. 2003 May;120(5):549-60
• All: 3 reference(s)