Atp1a2^tm1Kwk
Targeted Allele Detail

Summary

• Symbol: Atp1a2^tm1Kwk
• Name: ATPase, Na+/K+ transporting, alpha 2 polypeptide; targeted mutation 1, Kiyoshi Kawakami
• MGI ID: MGI:2664907
• Synonyms: Atp1a2^-, Atp1a2^tmCKwk, C-KO
• Gene: Atp1a2 Location: Chr1:172099276-172125631 bp, - strand Genetic Position: Chr1, 79.6 cM
• Alliance: Atp1a2^tm1Kwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83884
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGKneobpA cassette was inserted in exon 21. Lack of gene transcription in the brain was established by Northern blotting and the absence of protein in brain microsomal fractions of homozygous E18.5 embryos was then established on Western blots. (J:83884)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atp1a2 Mutation: 62 strains or lines available

References

• Original: J:83884 Ikeda K, et al., Degeneration of the amygdala/piriform cortex and enhanced fear/anxiety behaviors in sodium pump alpha2 subunit (Atp1a2)-deficient mice. J Neurosci. 2003 Jun 1;23(11):4667-76
• All: 4 reference(s)