Fcgr1^tm1Jsv
Targeted Allele Detail

Summary

• Symbol: Fcgr1^tm1Jsv
• Name: Fc receptor, IgG, high affinity I; targeted mutation 1, J Sjef Verbeek
• MGI ID: MGI:2664927
• Synonyms: FcgammaRI-, Fcgr1^tm1Sjv
• Gene: Fcgr1 Location: Chr3:96190225-96201285 bp, - strand Genetic Position: Chr3, 41.72 cM
• Alliance: Fcgr1^tm1Jsv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83995
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 3' part of the promoter, the exons encoding the L1 and L2 domains, and the 5' portion of the exon encoding the EC domain were deleted and replaced with a hygromycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by RT-PCR analysis of RNA from neutrophils, macrophages, and dendritic cells. (J:83995)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Fcgr1 Mutation: 35 strains or lines available

References

• Original: J:83995 Ioan-Facsinay A, et al., FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection. Immunity. 2002 Mar;16(3):391-402
• All: 52 reference(s)