Tg(Foxa3-cre)1Khk
Transgene Detail

Summary

• Symbol: Tg(Foxa3-cre)1Khk
• Name: transgene insertion 1, Klaus H Kaestner
• MGI ID: MGI:2664968
• Synonyms: Foxa3.cre, Foxa3-Cre, Foxa3cre, Foxa3Cre, Tg(Foxa3-cre)^1Khk
• Transgene: Tg(Foxa3-cre)1Khk Location: unknown
• Alliance: Tg(Foxa3-cre)1Khk page

Transgene origin

• Strain of Origin: (DBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Foxa3-cre)1Khk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Foxa3

• Mutation details: The transgenic construct consists of a 170 kb fragment containing a modified Foxa3 locus in which exon 2 has been replaced with an IRES-cre cassette. Cre activity was first detected 8.5 dpc in the anterior intestinal portal, and later in the entire gut endoderm from stomach to colon. Efficient cre-mediated recombination was demonstrated in the stomach, liver, pancreas, and colon. (J:96332)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Foxa3 (species not specified) Summary of all recombinase alleles driven by Foxa3. Comparative matrix view of recombinase activities

Disease models

Expression

In Mice Carrying this Mutation:

419 assay results 7 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Foxa3-cre)1Khk

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96332 Lee CS, et al., Foxa2 is required for the differentiation of pancreatic alpha-cells. Dev Biol. 2005 Feb 15;278(2):484-95
• All: 37 reference(s)