Tg(Alb1-cre)1Khk
Transgene Detail

Summary

• Symbol: Tg(Alb1-cre)1Khk
• Name: transgene insertion 1, Klaus H Kaestner
• MGI ID: MGI:2664969
• Synonyms: Afp-Alb-Cre, AFP>CRE, AFPp-Cre, Albafp.Cre, Alfp.cre, AlfpCre, Tg(Alb1-cre)^1Khk
• Transgene: Tg(Alb1-cre)1Khk Location: unknown
• Alliance: Tg(Alb1-cre)1Khk page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Alb1-cre)1Khk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Alb

• Mutation details: The transgenic construct contained an albumin promoter and an alpha fetoprotien enhancer adjoined to sequence encoding cre recombinase. Cre expression was driven in the developing liver. (J:84076)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Alb (species not specified) Summary of all recombinase alleles driven by Alb. Comparative matrix view of recombinase activities

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Foxa1^tm1Khk/Foxa1^tm1Khk Foxa2^tm1Khk/Foxa2^tm1Khk Tg(Alb1-cre)1Khk/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
cn2	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Lep^ob/Lep^ob Tg(Alb1-cre)1Khk/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL
cn3	Akt2^tm1.2Mbb/Akt2^tm1.2Mbb Tg(Alb1-cre)1Khk/0	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * SJL
cn4	Hhex^tm1Cwb/Hhex^tm2Cwb Tg(Alb1-cre)1Khk/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
cn5	Jag1^tm1.1Loo/Jag1^tm1.1Loo Tg(Alb1-cre)1Khk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
cn6	Jag1^tm1.1Loo/Jag1^+ Notch2^tm1Grid/Notch2^+ Tg(Alb1-cre)1Khk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
cn7	Jag1^tm1Grid/Jag1^tm1.1Loo Tg(Alb1-cre)1Khk/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
cn8	Hhex^tm2Cwb/Hhex^tm2Cwb Tg(Alb1-cre)1Khk/?	involves: 129S1/Sv * C57BL/6 * SJL
cn9	Foxm1^tm1Rhc/Foxm1^tm1Rhc Tg(Alb1-cre)1Khk/0	involves: 129X1/SvJ * C57BL/6 * SJL
cn10	Hnf4a^tm1Sad/Hnf4a^tm1Sad Tg(Alb1-cre)1Khk/0	involves: C57BL/6 * SJL

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5	cn6	cn7	cn8	cn9	cn10
show or hide all annotated terms
cardiovascular system									√
abnormal liver sinusoid morphology									√
abnormal hepatic vein morphology									√
cellular									√
abnormal cell cycle									√
endocrine/exocrine glands				√			√		√
abnormal bile duct development				√
abnormal intrahepatic bile duct morphology									√
bile duct proliferation							√
dilated bile duct							√
growth/size/body		√	N	√				√
growth/size/body region phenotype			N
decreased body weight		√
liver cyst				√				√
homeostasis/metabolism	√	√	√							√
increased circulating glucose level		√
decreased liver glycogen level										√
abnormal lipid homeostasis		√
decreased liver triglyceride level		√	√
decreased incidence of tumors by chemical induction	√
increased incidence of tumors by chemical induction	√
liver/biliary system	√	√	√	√			√	√	√	√
abnormal bile duct development				√
bile duct proliferation							√
dilated bile duct							√
abnormal hepatoblast morphology									√
decreased hepatoblast number									√
abnormal liver morphology				√						√
abnormal liver sinusoid morphology									√
abnormal intrahepatic bile duct morphology									√
liver cyst				√				√
decreased liver glycogen level										√
decreased liver triglyceride level		√	√
abnormal liver development										√
abnormal hepatic cord morphology									√
abnormal hepatocyte morphology										√
dissociated hepatocytes										√
decreased liver weight		√
increased hepatocellular carcinoma incidence	√
abnormal bile secretion							√
mortality/aging									√
lethality throughout fetal growth and development, incomplete penetrance									√
neoplasm	√
decreased incidence of tumors by chemical induction	√
increased incidence of tumors by chemical induction	√
increased hepatocellular carcinoma incidence	√
normal phenotype					√	√
no abnormal phenotype detected					√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

30 assay results 11 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:75121 Parviz F, et al., Generation of a conditionally null allele of hnf4alpha. Genesis. 2002 Feb;32(2):130-3
• All: 43 reference(s)