Klf4^tm1.1Khk
Targeted Allele Detail

Summary

• Symbol: Klf4^tm1.1Khk
• Name: Kruppel-like transcription factor 4 (gut); targeted mutation 1.1, Klaus H Kaestner
• MGI ID: MGI:2664975
• Synonyms: Klf4-
• Gene: Klf4 Location: Chr4:55527143-55532466 bp, - strand Genetic Position: Chr4, 29.76 cM
• Alliance: Klf4^tm1.1Khk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:76493
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed region encompassing exons 2 and 3 was excised from Klf4^tm1Khk via cre-mediated recombination in the germline. Absence of gene expression was confirmed by in situ hybridization of colon sections. (J:76493)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Klf4 Mutation: 26 strains or lines available

References

• Original: J:76493 Katz JP, et al., The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development. 2002 Jun;129(11):2619-28
• All: 8 reference(s)