Wnt11^tm1Amc
Targeted Allele Detail

Summary

• Symbol: Wnt11^tm1Amc
• Name: wingless-type MMTV integration site family, member 11; targeted mutation 1, Andrew P McMahon
• MGI ID: MGI:2665014
• Synonyms: Wnt11^-
• Gene: Wnt11 Location: Chr7:98484293-98503954 bp, + strand Genetic Position: Chr7, 53.9 cM
• Alliance: Wnt11^tm1Amc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83430
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exons 4 and 5 with a PGK-neo cassette via homologous recombination. RT-PCR analysis of RNA from homozygous mutant animals revealed a truncated transcription product predicted to encode 28 N-terminal amino acids. This mutant protein is expected to be non-functional. (J:83430)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Wnt11 Mutation: 22 strains or lines available

References

• Original: J:83430 Majumdar A, et al., Wnt11 and Ret/Gdnf pathways cooperate in regulating ureteric branching during metanephric kidney development. Development. 2003 Jul;130(14):3175-85
• All: 20 reference(s)