Pafah1b3^tm1Cla
Targeted Allele Detail

Summary

• Symbol: Pafah1b3^tm1Cla
• Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 3; targeted mutation 1, Gary D Clark
• MGI ID: MGI:2665018
• Synonyms: Alpha1^-
• Gene: Pafah1b3 Location: Chr7:24994473-24997377 bp, - strand Genetic Position: Chr7, 13.73 cM, cytoband A3
• Alliance: Pafah1b3^tm1Cla page

Testicular phenotypes of mice having various combinations of Pafah1b1^tm1Awb, Pafah1b2^{Gt(Betageo)1Cla} and Pafah1b3^tm1Cla alleles

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exonic active site was replaced by an HPRT mini gene under the control of the Pgk promoter. Northern blot analysis of homozygotes demonstrated the absence of gene products. (J:83818)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pafah1b3 Mutation: 13 strains or lines available

References

• Original: J:83818 Yan W, et al., Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7189-94
• All: 1 reference(s)