Pafah1b2^{Gt(Betageo)1Cla}
Gene trapped Allele Detail

Summary

• Symbol: Pafah1b2^{Gt(Betageo)1Cla}
• Name: platelet-activating factor acetylhydrolase, isoform 1b, subunit 2; gene trap 1, Gary D Clark
• MGI ID: MGI:2665020
• Synonyms: Alpha2^-/-
• Gene: Pafah1b2 Location: Chr9:45876609-45923988 bp, - strand Genetic Position: Chr9, 25.36 cM
• Alliance: Pafah1b2^{Gt(Betageo)1Cla} page

Testicular phenotypes of mice having various combinations of Pafah1b1^tm1Awb, Pafah1b2^{Gt(Betageo)1Cla} and Pafah1b3^tm1Cla alleles

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83818
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: Gene disruption was achieved by a modified gene-trapping strategy resulting in duplication of genomic sequence with a Beta-geo cassette inserted between the duplicates. Northern blot analysis proved that no gene product was present in homozygotes. (J:83818)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pafah1b2 Mutation: 20 strains or lines available

References

• Original: J:83818 Yan W, et al., Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7189-94
• All: 2 reference(s)