Tg(Igh-Abl1)40Sco
Transgene Detail

Summary

• Symbol: Tg(Igh-Abl1)40Sco
• Name: transgene insertion 40, Suzanne Cory
• MGI ID: MGI:2665029
• Synonyms: EmuSV-v-abl, Emu-v-abl
• Transgene: Tg(Igh-Abl1)40Sco Location: unknown Genetic Position: Chr14, Syntenic
• Alliance: Tg(Igh-Abl1)40Sco page

Transgene origin

• Strain of Origin: (C57BL/6JWehi X SJL/JWehi)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh-Abl1)40Sco expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Abl1 (MGI:87859)

• Mutation details: The transgene used the mouse Igh enhancer and the SV40 early promoter region to drive a gag-Abl1 fusion sequence in lymphoid cells. The transgene is expressed in hematopoietic tissues and in all tumors. (J:78204)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Four transgenic lines were created. Line v-abl 1 harbors more than 1 transgene and exhibits only lymphomas (will be described elswhere). Lines v-abl 40, v-abl 8, and v-abl 2 develop plasmocytomas.

References

• Original: J:78204 Rosenbaum H, et al., An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene. EMBO J. 1990 Mar;9(3):897-905
• All: 7 reference(s)