Hbegf^tm1Dcl
Targeted Allele Detail

Summary

• Symbol: Hbegf^tm1Dcl
• Name: heparin-binding EGF-like growth factor; targeted mutation 1, David C Lee
• MGI ID: MGI:2665039
• Synonyms: HB-EGF^-
• Gene: Hbegf Location: Chr18:36637980-36648858 bp, - strand Genetic Position: Chr18, 19.46 cM
• Alliance: Hbegf^tm1Dcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83820
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1 and 2 were replaced with PGK-Neo, deleting the signal peptide, propeptide and inducing a frame shift to prevent translational readthrough. Northern blots confirmed the absence of gene transcripts. (J:83820)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hbegf Mutation: 26 strains or lines available

References

• Original: J:83820 Jackson LF, et al., Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J. 2003 Jun 2;22(11):2704-16
• All: 15 reference(s)