Btc^tm1Dcl
Targeted Allele Detail

Summary

• Symbol: Btc^tm1Dcl
• Name: betacellulin, epidermal growth factor family member; targeted mutation 1, David C Lee
• MGI ID: MGI:2665044
• Synonyms: Btc^-
• Gene: Btc Location: Chr5:91505120-91550853 bp, - strand Genetic Position: Chr5, 44.78 cM
• Alliance: Btc^tm1Dcl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83820
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: PGK-Neo replaced exon 3 which encodes for the first two loops of EGF-like sequence that are critical for receptor binding. Northern blots confirmed the absence of gene transcripts. (J:83820)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Btc Mutation: 17 strains or lines available

References

• Original: J:83820 Jackson LF, et al., Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling. EMBO J. 2003 Jun 2;22(11):2704-16
• All: 4 reference(s)