Cd81tm1Tmiy
Targeted Allele Detail
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Symbol: |
Cd81tm1Tmiy |
Name: |
CD81 antigen; targeted mutation 1, Toru Miyazaki |
MGI ID: |
MGI:2665072 |
Synonyms: |
CD81- |
Gene: |
Cd81 Location: Chr7:142606487-142621667 bp, + strand Genetic Position: Chr7, 88.1 cM
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Alliance: |
Cd81tm1Tmiy page
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Germline Transmission: |
Earliest citation of germline transmission:
J:41830
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 3 through 7 and part of exon 8 (including the TGA stop codon) were replaced with a Neomycin resistance gene. These exons encode the second extracellular loop, the second through fourth membrane spanning domains and the entire C-terminal intracellular domain. Absence of gene expression was established by Northern blot analysis and RT-PCR and absence of protein was confirmed by cytofluorometric analysis of splenic B cells.
(J:41830)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cd81 Mutation: |
22 strains or lines available
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Original: |
J:41830 Miyazaki T, et al., Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J. 1997 Jul 16;16(14):4217-25 |
All: |
8 reference(s) |
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