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Cd81tm1Tmiy
Targeted Allele Detail
Summary
Symbol: Cd81tm1Tmiy
Name: CD81 antigen; targeted mutation 1, Toru Miyazaki
MGI ID: MGI:2665072
Synonyms: CD81-
Gene: Cd81  Location: Chr7:142606487-142621667 bp, + strand  Genetic Position: Chr7, 88.1 cM
Alliance: Cd81tm1Tmiy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41830
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 7 and part of exon 8 (including the TGA stop codon) were replaced with a Neomycin resistance gene. These exons encode the second extracellular loop, the second through fourth membrane spanning domains and the entire C-terminal intracellular domain. Absence of gene expression was established by Northern blot analysis and RT-PCR and absence of protein was confirmed by cytofluorometric analysis of splenic B cells. (J:41830)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd81 Mutation:  22 strains or lines available
References
Original:  J:41830 Miyazaki T, et al., Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J. 1997 Jul 16;16(14):4217-25
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory