Hscfr^AKR/J
QTL Variant Detail

Summary

• QTL variant: Hscfr^AKR/J
• Name: hematopoietic stem cell frequency regulator; AKR/J
• MGI ID: MGI:2665083
• QTL: Hscfr Location: unknown Genetic Position: Chr17, cM position of peak correlated region/allele: 23.5 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: AKR/J

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased hematopoietic stem cell frequencies compared to C57BL/6Ka. (J:73737)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:73737

Interval mapping was performed on phenotypically extreme animals from a (C57BL/6Ka-Thy1 x AKR/J)F2 intercross to identify QTLs associated with hematopoietic stem cell (HSC) regulation. Parental strain AKR/J exhibits a higher number of long-term reconstituting HSCs compared to parental strain C57BL/Ka-Thy1. A significant locus mapped to approximately 20 cM on mouse Chromosome 17 and is named Hscfr (hematopoietic stem cell frequency regulator). The QTL interval of Hscfr spans 9.8 cM to 33.8 cM, and the peakLOD score is 4.85 at D17Mit65 and D17Mit66. The AKR/J-derived allele is associated with increased HSC frequencies. When an AKR/J-derived region of Hscfr from D7Mit31 to D17Mit87 was bred onto a C57BL/6 background the phenotype was lost. Authors conclude that Hscfr alone is not sufficient to increase HSCs on a C57BL/6 background. Potential candidate genes for Hscfr are Notch3 and Notch4.

References

• Original: J:73737 Morrison SJ, et al., A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol. 2002 Jan 15;168(2):635-42
• All: 1 reference(s)