Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Pcyts2 exhibit additive inheritance.
Mapping and Phenotype information for this QTL, its variants and associated markersJ:78523The Tg(Igh-Abl1)2Sco transgene was constructed on a (C57BL/6JWehi X SJL/JWehi)F1 background and was transferred onto a C57BL/6J background and a BALB/cAnBrdWehi background by sucessive backcrossing. Transgenic animals on the BALB/cAnBrdWehi background are more susceptible to plasmatycoma development than transgenic animals on a C57BL/6J background. Transgenic C57BL/6J animals were crossed to BALB/c mice. Transgenic F2 animals were susequently generated. These animals were screened for 191 polymorphic markers at an average resolution of 10 cM to identify QTLs associated with susceptibility to plasmacytoma.Plasmacytoma susceptibility 1 (Pcyts1) mapped to 69 cM on mouse Chromosome 2 with a peak LOD score of 6.1 at D2Mit17. BALB/c-derived alleles confer plasmacytoma susceptibility in male animals with additive inheritance. Possible interaction was detected between Pcyts5-Pcyts1.Pcyts2 maps to 12 cM on mouse Chromosome 4 with a peak LOD score of 5.2 at D4Mit236. BALB/c-derived alleles confer additively inherited plasmacytoma susceptibility. Pcyts3 maps to 49 cM on mouse Chromosome 11 with a peak LOD score of 5.5 at D11Mit39. BALB/c-derived alleles confer dominantly inherited plasmacytoma susceptibility at Pcyts3. Possible interaction was detected between Pcyts5-Pcyts3.Pcyts4 and Pcyts5 mapped to 8 cM and 34 cM on mouse Chromosome 17, respectively. Pcyts4 gives a peak LOD score of 5.6 at D17Mit57 with BALB/c-derived alleles conferring additively inherited plasmacytoma susceptibility in female animals. Pcyts5 gives a peak LOD score of 6.6 at D17Mit87 with BALB/c-derived alleles conferring additively inherited plasmacytoma susceptibility in female animals. Possible interactions were detected between Pcyts5-Pcyts1 and Pcyts5-Pcyts3.Pcyts6 maps to 25cM on mouse Chromosome 18 with a peak LOD score of 7.8 at D18Mit74. C57BL/6J-derived alleles confer additively inherited plasmacytoma susceptibility at Pcyts6. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 10/29/2024 MGI 6.24 |
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