Pde6b^rd1-2J
Chemically induced Allele Detail

Summary

• Symbol: Pde6b^rd1-2J
• Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; retinal degeneration 1, 2 Jackson
• MGI ID: MGI:2665102
• Synonyms: neuroscience mutagenesis facility, 137, nmf137, NMF137, Pde6b^2J, Pde6b^nmf137
• Gene: Pde6b Location: Chr5:108536239-108579609 bp, + strand Genetic Position: Chr5, 53.07 cM
• Alliance: Pde6b^rd1-2J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: This mutation was shown by genetic complementation analysis to be an allele of Pde6b. Molecular sequence analysis showed that this mutation corresponds to a point mutation in exon 16. (J:122722)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pde6b Mutation: 122 strains or lines available

References

• Original: J:122722 Chang B, et al., Two mouse retinal degenerations caused by missense mutations in the beta-subunit of rod cGMP phosphodiesterase gene. Vision Res. 2007 Mar;47(5):624-33
• All: 13 reference(s)