Tg(TcrLCMV)327Sdz
Transgene Detail

Summary

• Symbol: Tg(TcrLCMV)327Sdz
• Name: transgene insertion 327, Birgit Ledermann
• MGI ID: MGI:2665105
• Synonyms: P14, P14 TCR, P14-TCR, P14 TCR-alphabeta (Valpha2Vbeta8.1), P14 TCRValpha2Vbeta8, TCR LCMV, TCR P14, TCR-Tg, TgTcr
• Transgene: Tg(TcrLCMV)327Sdz Location: unknown
• Alliance: Tg(TcrLCMV)327Sdz page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcrLCMV)327Sdz expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: The transgene carries both Tcra and Tcrb. Ten to twenty copies of the Tcr transgene were reported to have integrated on the same chromosome. At least two transgenic lines are known to exist. Line 327 is the representative line. The second line is 318. (J:77696)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 8 strains available Cell Lines: 0 lines available

Notes

Transgenic mice carry a T-cell receptor (Tcra-V2, Tcra-J TA31 / Tcrb-V8.1, Tcrb-D, Tcrb-J 2.4) specific for the gp33 protein of LCMV (lymphocytic choriomeningitis virus), H2-D^b.

References

• Original: J:77696 Pircher H, et al., Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature. 1989 Nov 30;342(6249):559-61
• All: 370 reference(s)