Mark2^{Gt(pSABetageo)38Bss}
Gene trapped Allele Detail

Summary

• Symbol: Mark2^{Gt(pSABetageo)38Bss}
• Name: MAP/microtubule affinity regulating kinase 2; gene trap 38, Stephanie Bessone
• MGI ID: MGI:2665175
• Gene: Mark2 Location: Chr19:7252761-7319222 bp, - strand Genetic Position: Chr19, 5.32 cM, cytoband B
• Alliance: Mark2^{Gt(pSABetageo)38Bss} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57958
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The endogenous locus was disrupted by the random integration of a gene trap vector containing a splice acceptor site followed by beta-geo. Sequence and RT-PCR analysis showed that the insertion was intronic and was in between the start codon and sequence encoding the kinase domain. (J:57958)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mark2 Mutation: 109 strains or lines available

References

• Original: J:57958 Bessone S, et al., EMK protein kinase-null mice: dwarfism and hypofertility associated with alterations in the somatotrope and prolactin pathways. Dev Biol. 1999 Oct 1;214(1):87-101
• All: 3 reference(s)