Tg(Tcra,Tcrb)3Ayr
Transgene Detail

Summary

• Symbol: Tg(Tcra,Tcrb)3Ayr
• Name: transgene insertion 3, Alexander Y Rudensky
• MGI ID: MGI:2665469
• Synonyms: TEa, TEa TCR, Tg(Tcra/Tcrb)1Ayr
• Transgene: Tg(Tcra,Tcrb)3Ayr Location: unknown
• Alliance: Tg(Tcra,Tcrb)3Ayr page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tcra,Tcrb)3Ayr expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: Rearranged Tcra and Tcrb cDNA sequences derived from a Valpha2Vbeta6-expressing T cell hybridoma, p8.3, were used for the transgene constructs. (J:84193)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:84193 Grubin CE, et al., Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. Immunity. 1997 Aug;7(2):197-208
• All: 41 reference(s)