Pcsk4^tm1Mbi
Targeted Allele Detail

Summary

• Symbol: Pcsk4^tm1Mbi
• Name: proprotein convertase subtilisin/kexin type 4; targeted mutation 1, Majambu Mbikay
• MGI ID: MGI:2665512
• Synonyms: Pcsk4^-
• Gene: Pcsk4 Location: Chr10:80157117-80165332 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Pcsk4^tm1Mbi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41503
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment encompassing exons 3 through 6 was replaced with a cassette containing lacZ and neo. The deleted region encoded 2 of the 4 residues of the catalytic domain. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant testes. (J:41503)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pcsk4 Mutation: 45 strains or lines available

References

• Original: J:41503 Mbikay M, et al., Impaired fertility in mice deficient for the testicular germ-cell protease PC4. Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6842-6
• All: 6 reference(s)