H1f2^tm2Ais
Targeted Allele Detail

Summary

• Symbol: H1f2^tm2Ais
• Name: H1.2 linker histone, cluster member; targeted mutation 2, Arthur I Skoutchi
• MGI ID: MGI:2665852
• Synonyms: H1c^-
• Gene: H1f2 Location: Chr13:23922790-23923514 bp, + strand Genetic Position: Chr13, 9.9 cM, cytoband A2-A3
• Alliance: H1f2^tm2Ais page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83954
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Most of the coding region, including the start site was replaced with a PGK-Hygro cassette. Lack of gene product was confirmed by reverse phase HPLC. (J:83954)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any H1f2 Mutation: 16 strains or lines available

References

• Original: J:83954 Fan Y, et al., H1 linker histones are essential for mouse development and affect nucleosome spacing in vivo. Mol Cell Biol. 2003 Jul;23(13):4559-72
• All: 3 reference(s)