Blnk^tm1Dkit
Targeted Allele Detail

Summary

• Symbol: Blnk^tm1Dkit
• Name: B cell linker; targeted mutation 1, Daisuke Kitamura
• MGI ID: MGI:2665856
• Synonyms: BASH-
• Gene: Blnk Location: Chr19:40917371-40982664 bp, - strand Genetic Position: Chr19, 34.26 cM
• Alliance: Blnk^tm1Dkit page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84040
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by a polyadenylation signal inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant splenic cells. Germline transmission of the allele generated in J:80920 was achieved in J:85014. (J:80920, J:84040)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Blnk Mutation: 78 strains or lines available

References

• Original: J:84040 Hayashi K, et al., Distinct signaling requirements for Dmu selection, IgH allelic exclusion, pre-B cell transition, and tumor suppression in B cell progenitors. Immunity. 2003 Jun;18(6):825-36
• All: 9 reference(s)