Slc8a2^tm1(cre)Hssh
Targeted Allele Detail

Summary

• Symbol: Slc8a2^tm1(cre)Hssh
• Name: solute carrier family 8 (sodium/calcium exchanger), member 2; targeted mutation 1, Hee-Sup Shin
• MGI ID: MGI:2667136
• Synonyms: NCX2^-
• Gene: Slc8a2 Location: Chr7:15863751-15894988 bp, + strand Genetic Position: Chr7, 8.75 cM
• Alliance: Slc8a2^tm1(cre)Hssh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84050
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Slc8a2^tm1(cre)Hssh expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc8a2 (MGI:107996)

• Mutation details: The coding region of exon 1 was replaced with a cassette containing nls-cre and neo. Protein was undetected by Western blot analysis of homozygous mutant mice. Expression of cre was verified by Northern blot analysis and the observed recombination of a reporter transgene. (J:84050)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc8a2 (mouse) Summary of all recombinase alleles driven by Slc8a2. Alliance mouse Slc8a2 gene page

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc8a2 Mutation: 43 strains or lines available

References

• Original: J:84050 Jeon D, et al., Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2. Neuron. 2003 Jun 19;38(6):965-76
• All: 8 reference(s)