Nck1^tm1Paw
Targeted Allele Detail

Summary

• Symbol: Nck1^tm1Paw
• Name: non-catalytic region of tyrosine kinase adaptor protein 1; targeted mutation 1, Tony Pawson
• MGI ID: MGI:2667151
• Synonyms: Nck1^-, Nck1^IRES-lacZ
• Gene: Nck1 Location: Chr9:100376047-100428187 bp, - strand Genetic Position: Chr9, 52.69 cM
• Alliance: Nck1^tm1Paw page

Morphometric analysis of aortic root lesions in tamoxifen-treated, high-fat diet fed Apoe^tm1Unc/Apoe^tm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1^tm1Paw/Nck1^tm1Paw Nck2^tm3Paw/Nck2^tm3Paw mice.

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83956
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: An IRES-beta-galactosidase cassette was inserted into the first coding exon 29 nucleotides downstream from the start codon. This disrupts one of three SH3 domains. (J:83956)

Expression

In Mice Carrying this Mutation:

67 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Nck1 Mutation: 40 strains or lines available

References

• Original: J:83956 Bladt F, et al., The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97
• All: 24 reference(s)