Nck2^tm1Paw
Targeted Allele Detail

Summary

• Symbol: Nck2^tm1Paw
• Name: non-catalytic region of tyrosine kinase adaptor protein 2; targeted mutation 1, Tony Pawson
• MGI ID: MGI:2667153
• Synonyms: Nck2^ko
• Gene: Nck2 Location: Chr1:43484643-43609678 bp, + strand Genetic Position: Chr1, 23.18 cM, cytoband C1
• Alliance: Nck2^tm1Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83956
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was replaced by a pkg-Neo cassette. In the process, one of three SH3 domains is eliminated. (J:83956)

Expression

In Mice Carrying this Mutation:

34 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nck2 Mutation: 29 strains or lines available

References

• Original: J:83956 Bladt F, et al., The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97
• All: 7 reference(s)