Nck2^tm2Paw
Targeted Allele Detail

Summary

• Symbol: Nck2^tm2Paw
• Name: non-catalytic region of tyrosine kinase adaptor protein 2; targeted mutation 2, Tony Pawson
• MGI ID: MGI:2667154
• Synonyms: Nick2^tau-lacZ
• Gene: Nck2 Location: Chr1:43484643-43609678 bp, + strand Genetic Position: Chr1, 23.18 cM, cytoband C1
• Alliance: Nck2^tm2Paw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83956
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A tau-beta-galactosidase cassette replaced the C-terminal part of the first coding exon (amino acids 22-76) as well as part of the following intron. In the process most of an SH3 domain is eliminated. (J:83956)

Expression

In Mice Carrying this Mutation:

67 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nck2 Mutation: 29 strains or lines available

References

• Original: J:83956 Bladt F, et al., The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97
• All: 1 reference(s)