Drap1^tm1Mms
Targeted Allele Detail

Summary

• Symbol: Drap1^tm1Mms
• Name: DR1 associated protein 1; targeted mutation 1, Michael M Shen
• MGI ID: MGI:2667159
• Synonyms: Drap1^-
• Gene: Drap1 Location: Chr19:5472833-5475007 bp, - strand Genetic Position: Chr19, 4.32 cM, cytoband A
• Alliance: Drap1^tm1Mms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80667
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequence encompassing all of exon 2 and a portion of exon 3 was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded amino acids 13 through 65, which make up a portion of the alpha helix of the mature protein. (J:80667)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Drap1 Mutation: 10 strains or lines available

References

• Original: J:80667 Iratni R, et al., Inhibition of excess nodal signaling during mouse gastrulation by the transcriptional corepressor DRAP1. Science. 2002 Dec 6;298(5600):1996-9
• All: 1 reference(s)