Ikzf1^tm1Kast
Targeted Allele Detail

Summary

• Symbol: Ikzf1^tm1Kast
• Name: IKAROS family zinc finger 1; targeted mutation 1, Philippe Kastner
• MGI ID: MGI:2667175
• Synonyms: Ik^L
• Gene: Ikzf1 Location: Chr11:11634980-11722926 bp, + strand Genetic Position: Chr11, 7.02 cM
• Alliance: Ikzf1^tm1Kast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82813
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Exon 2, which is common to all known isoforms, was disrupted by the in frame insertion of beta-geo and floxed neo. Full length protein was undetected by Western blot analysis of homozygous mutant bone marrow, spleen, and thymus, though truncated polypeptides, translated from transcripts with aberrant splicing from exon 1 to 3, were identified in the spleen and thymus. Low levels of protein arising from the targeted locus were detected by immunohistochemical analysis of homozygous mutant splenocytes. (J:82813)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ikzf1^tm1Kast

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ikzf1 Mutation: 30 strains or lines available

References

• Original: J:82813 Kirstetter P, et al., Ikaros is critical for B cell differentiation and function. Eur J Immunol. 2002 Mar;32(3):720-30
• All: 17 reference(s)