Stap2^tm1Ayos
Targeted Allele Detail

Summary

• Symbol: Stap2^tm1Ayos
• Name: signal transducing adaptor family member 2; targeted mutation 1, Akihiko Yoshimura
• MGI ID: MGI:2667181
• Synonyms: STAP-2
• Gene: Stap2 Location: Chr17:56304077-56312584 bp, - strand Genetic Position: Chr17, 29.1 cM
• Alliance: Stap2^tm1Ayos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82584
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 through 13, encoding the carboxyl portion of the PH domain and the entire SH2 domain, was replaced with a neomycin selection cassette. Northern blot analysis of homozygous mutant mice indicated an absence of transcript. (J:82584)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stap2 Mutation: 24 strains or lines available

References

• Original: J:82584 Minoguchi M, et al., STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif. J Biol Chem. 2003 Mar 28;278(13):11182-9
• All: 7 reference(s)