Tab1^tm1Geny
Targeted Allele Detail

Summary

• Symbol: Tab1^tm1Geny
• Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1; targeted mutation 1, Gen Yamada
• MGI ID: MGI:2667182
• Gene: Tab1 Location: Chr15:80017333-80045908 bp, + strand Genetic Position: Chr15, 37.85 cM, cytoband E2
• Alliance: Tab1^tm1Geny page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80766
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced two exons encoding amino acids 308 through 336. Normal protein was undetected by Western blot analysis of homozygous mutant MEFs. (J:80766)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tab1 Mutation: 91 strains or lines available

References

• Original: J:80766 Komatsu Y, et al., Targeted disruption of the Tab1 gene causes embryonic lethality and defects in cardiovascular and lung morphogenesis. Mech Dev. 2002 Dec;119 Suppl 1(2):239-49
• All: 2 reference(s)