Gab1^tm1Ajw
Targeted Allele Detail

Summary

• Symbol: Gab1^tm1Ajw
• Name: growth factor receptor bound protein 2-associated protein 1; targeted mutation 1, Albert J Wong
• MGI ID: MGI:2667211
• Synonyms: Gab1^-
• Gene: Gab1 Location: Chr8:81491067-81607148 bp, - strand Genetic Position: Chr8, 38.47 cM, cytoband C3
• Alliance: Gab1^tm1Ajw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83953
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which contains part of the PH domain, was replaced with a neomycin resistance gene. Homologous recombination was confirmed in heterozygous mice and homozygous embryos by PCR and by Western blots. (J:83953)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gab1 Mutation: 78 strains or lines available

References

• Original: J:83953 Holgado-Madruga M, et al., Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol. 2003 Jul;23(13):4471-84
• All: 1 reference(s)