Nfkb2^xdr
Chemically induced Allele Detail

Summary

• Symbol: Nfkb2^xdr
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; xander
• MGI ID: MGI:2667230
• Synonyms: xdr
• Gene: Nfkb2 Location: Chr19:46292759-46300824 bp, + strand Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
• Alliance: Nfkb2^xdr page

Mutation origin

• Strain of Origin: C57BL/6JSfdAnu
• Project Collection: APF ENU Mutagenesis

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T-to-A point mutation at nucleotide 3193 disrupted the exon 7 splice acceptor site within intron 6. Normal protein was undetected by Western blot analysis of homozygous mutant mice. The mutation resulted in an accumulation of unspliced intermediates as well as mutant transcripts that involved aberrant splicing of exon 6 to sites within exon 7 and premature stop codons. (J:79725)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfkb2 Mutation: 49 strains or lines available

References

• Original: J:79725 Miosge LA, et al., Analysis of an Ethylnitrosourea-generated Mouse Mutation Defines a Cell Intrinsic Role of Nuclear Factor kappaB2 in Regulating Circulating B Cell Numbers. J Exp Med. 2002 Oct 21;196(8):1113-9
• All: 5 reference(s)