Plcd1^tm1Tta
Targeted Allele Detail

Summary

• Symbol: Plcd1^tm1Tta
• Name: phospholipase C, delta 1; targeted mutation 1, Tadaomi Takenawa
• MGI ID: MGI:2667234
• Synonyms: PLCdelta-deficient, PLCgamma1^-
• Gene: Plcd1 Location: Chr9:118900595-118922570 bp, - strand Genetic Position: Chr9, 71.32 cM
• Alliance: Plcd1^tm1Tta page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83948
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequences encoding the X and Y (catalytic) domains were replaced with a neomycin resistance cassette. Western blot analysis of testes proteins from homozygotes indicated the absence of gene product. Use of antibodies specific for the N-terminal 60 amino acids confirmed that no product was present. (J:83948)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plcd1 Mutation: 44 strains or lines available

References

• Original: J:83948 Nakamura Y, et al., Phospholipase Cdelta1 is required for skin stem cell lineage commitment. EMBO J. 2003 Jun 16;22(12):2981-91
• All: 13 reference(s)