Hivep3^tm1Lcw
Targeted Allele Detail

Summary

• Symbol: Hivep3^tm1Lcw
• Name: human immunodeficiency virus type I enhancer binding protein 3; targeted mutation 1, Lai-Chu Wu
• MGI ID: MGI:2667235
• Synonyms: KRC^-
• Gene: Hivep3 Location: Chr4:119590982-119992608 bp, + strand Genetic Position: Chr4, 55.51 cM, cytoband D1
• Alliance: Hivep3^tm1Lcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266689
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 486 bp fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region corresponded to nucleotides 954 through 1440 of the cDNA and encoded the first zinc finger pairs. The insertion of the cassette was reported to disrupt the open reading frame at codon 99. Protein was undetected by Western blot analysis of homozygous mutant mice. (J:79652)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Hivep3^tm1Lcw

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hivep3 Mutation: 104 strains or lines available

Notes

J:79652 reports the phenotypic analysis of chimeric mice made by injecting Hivep3^-/- ES cells into Rag2^-/- blastocyts. The chimeras were estimated to be composed of greater than 50% Hivep3^tm1Lcw/Hivep3^tm1Lcw derived cells.

References

• Original: J:79652 Allen CE, et al., Developmental anomalies and neoplasia in animals and cells deficient in the large zinc finger protein KRC. Genes Chromosomes Cancer. 2002 Dec;35(4):287-98
• All: 3 reference(s)