Nsd1^tm1.1Pcn
Targeted Allele Detail

Summary

• Symbol: Nsd1^tm1.1Pcn
• Name: nuclear receptor-binding SET-domain protein 1; targeted mutation 1.1, Pierre Chambon
• MGI ID: MGI:2667262
• Synonyms: NSD1^-
• Gene: Nsd1 Location: Chr13:55357595-55466138 bp, + strand Genetic Position: Chr13, 29.8 cM
• Alliance: Nsd1^tm1.1Pcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83923
• Parent Cell Line: P1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated by crossing mice heterozygous for Nsd1^tm1Pcn with cytomegalovirus-Cre mice which express the Cre recombinase in the germline. Animals in which Cre-mediated excision of the neomycin gene and exon 2 occurred were detected by PCR analysis. (J:83923)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsd1 Mutation: 279 strains or lines available

References

• Original: J:83923 Rayasam GV, et al., NSD1 is essential for early post-implantation development and has a catalytically active SET domain. EMBO J. 2003 Jun 16;22(12):3153-63
• All: 2 reference(s)