Slc27a4^tm1Wsr
Targeted Allele Detail

Summary

• Symbol: Slc27a4^tm1Wsr
• Name: solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Wolfgang Stremmel
• MGI ID: MGI:2667328
• Synonyms: Fatp4^-, Fatp4^flox, Fatp4-K
• Gene: Slc27a4 Location: Chr2:29692646-29707534 bp, + strand Genetic Position: Chr2, 20.64 cM, cytoband B
• Alliance: Slc27a4^tm1Wsr page

Abnormal appearance of Slc27a4^tm1Wsr/Slc27a4^tm1Wsr mice, with facial dysmorphia, skin abnormalities and a rigid torso

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84096
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A 7172 bp insert containing a splice acceptor, IRES, lacZ reporter gene and a neomycin resistance gene, all flanked by two FLP recombinase target sites was placed in intron 2 at the same time that loxP sites were inserted on either side of exon 3. Northern blot analysis established the absence of mRNA transcripts from the targeted gene and Western blots demonstrated the absence of protein products. (J:84096)

Disease models

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc27a4 Mutation: 37 strains or lines available

References

• Original: J:84096 Herrmann T, et al., Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol. 2003 Jun 23;161(6):1105-15
• All: 7 reference(s)