Slc27a4^tm1.1Wsr
Targeted Allele Detail

Summary

• Symbol: Slc27a4^tm1.1Wsr
• Name: solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1.1, Wolfgang Stremmel
• MGI ID: MGI:2667329
• Synonyms: Fatp4^-/-, Fatp4^deltaEx3, Fatp4-KO
• Gene: Slc27a4 Location: Chr2:29692646-29707534 bp, + strand Genetic Position: Chr2, 20.64 cM, cytoband B
• Alliance: Slc27a4^tm1.1Wsr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84096
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele was generated from Slc27a4^tm1Wsr by crossing mutant mice with mice transgenic for PGK-Cre. This resulted in the excision of exon 3 as a result of the ubiquitously expressed Cre activity. Northern blot and Western blot analyses demonstrated the absence of transcripts and protein products. (J:84096)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc27a4 Mutation: 37 strains or lines available

References

• Original: J:84096 Herrmann T, et al., Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol. 2003 Jun 23;161(6):1105-15
• All: 4 reference(s)