Tbxa2r^tm1Sna
Targeted Allele Detail

Summary

• Symbol: Tbxa2r^tm1Sna
• Name: thromboxane A2 receptor; targeted mutation 1, Shuh Narumiya
• MGI ID: MGI:2667333
• Synonyms: TP^-, TP-deficient
• Gene: Tbxa2r Location: Chr10:81164565-81171006 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Tbxa2r^tm1Sna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84085
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 and part of exon 3 were replaced with a neomycin resistance gene. This results in a deletion from the N terminus to the sixth transmembrane domain. Functional disruption of the gene was confirmed by loss of platelet aggregation in response to the thromboxane receptor agonist, I-BOP as well as by the absence of ligand binding activity in thymocytes. (J:84085)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tbxa2r^tm1Sna

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tbxa2r Mutation: 18 strains or lines available

References

• Original: J:84085 Kabashima K, et al., Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity. Nat Immunol. 2003 Jul;4(7):694-701
• All: 24 reference(s)