Tg(Krt14-dnLef1)LFmw
Transgene Detail

Summary

• Symbol: Tg(Krt14-dnLef1)LFmw
• Name: transgene insertion L, Fiona M Watt
• MGI ID: MGI:2667375
• Synonyms: K14deltaNLef1, Tg(K14DNLef1)1FMW
• Transgene: Tg(Krt14-dnLef1)LFmw Location: unknown
• Alliance: Tg(Krt14-dnLef1)LFmw page

Transgene origin

• Strain of Origin: (CBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Krt14-dnLef1)LFmw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Lef1 (MGI:96770)

• Mutation details: An N terminally deleted mouse Lef1 cDNA (lacking the first 32 amino acids, including the beta catenin binding site) was expressed under the control of the keratin 14 promoter. Copy number of the transgenic line was 25. (J:73649)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:73649 Niemann C, et al., Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development. 2002 Jan;129(1):95-109
• All: 16 reference(s)