Spen^tm1Hon
Targeted Allele Detail

Summary

• Symbol: Spen^tm1Hon
• Name: spen family transcription repressor; targeted mutation 1, Tasuku Honjo
• MGI ID: MGI:2667509
• Synonyms: MINT^-
• Gene: Spen Location: Chr4:141195201-141265908 bp, - strand Genetic Position: Chr4, 74.26 cM, cytoband E1
• Alliance: Spen^tm1Hon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:82332
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 12, upstream of sequence encoding the MSXB domain. Truncated transcript was identified by Northern blot analysis of homozygous mice at E12.5. (J:82332)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Spen Mutation: 140 strains or lines available

References

• Original: J:82332 Kuroda K, et al., Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity. 2003 Feb;18(2):301-12
• All: 2 reference(s)