Ntrk2^tm1.1Lfr
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm1.1Lfr
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1.1, Louis F Reichardt
• MGI ID: MGI:2667686
• Synonyms: trkB^lacZ
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm1.1Lfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:84073
• Parent Cell Line: JM-1 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed Ntrk2 cDNA was removed from Ntrk2^tm1Lfr leaving a single loxP site and the tau-lacZ cassette in place at the endogenous locus. Beta-galactosidase is expressed under the control of the endogenous promoter. (J:69123)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:84073 Xu B, et al., Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat Neurosci. 2003 Jul;6(7):736-42
• All: 13 reference(s)