Mgat2^tm1.1Jxm
Targeted Allele Detail

Summary

• Symbol: Mgat2^tm1.1Jxm
• Name: mannoside acetylglucosaminyltransferase 2; targeted mutation 1.1, Jamey Marth
• MGI ID: MGI:2667740
• Synonyms: Mgat2^delta
• Gene: Mgat2 Location: Chr12:69230931-69233544 bp, + strand Genetic Position: Chr12, 28.73 cM
• Alliance: Mgat2^tm1.1Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80661
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region, which is contained within a single exon, was deleted when the flanking loxP sites present in Mgat2^tm1Jxm were recombined in the germline. (J:80661)

Disease models

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mgat2 Mutation: 16 strains or lines available

References

• Original: J:80661 Wang Y, et al., Modeling human congenital disorder of glycosylation type IIa in the mouse: conservation of asparagine-linked glycan-dependent functions in mammalian physiology and insights into disease pathogenesis. Glycobiology. 2001 Dec;11(12):1051-70
• All: 3 reference(s)