Ifnar1^tm1Pjh
Targeted Allele Detail

Summary

• Symbol: Ifnar1^tm1Pjh
• Name: interferon (alpha and beta) receptor 1; targeted mutation 1, Paul J Hertzog
• MGI ID: MGI:2667975
• Synonyms: IFNAR1 -
• Gene: Ifnar1 Location: Chr16:91282126-91304329 bp, + strand Genetic Position: Chr16, 52.98 cM
• Alliance: Ifnar1^tm1Pjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:36004
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The endogenous locus was disrupted by the insertion of a neo cassette into exon 5. Transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:36004)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifnar1 Mutation: 60 strains or lines available

References

• Original: J:36004 Hwang SY, et al., A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses. Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11284-8
• All: 51 reference(s)